Similarly, the overall success rate of crystallography (less than 10%) is not discussed. A clear and very useful distinction is drawn between “similarity” and “homology,” giving examples.Īlthough ab initio structure prediction of novel folds from sequence is introduced nicely in Chapter 5, and critical assessment of structure prediction is mentioned, the present success levels are not quantitated, nor is it made clear that for most purposes useful predictions of tertiary structure cannot be achieved from sequence alone.
Students will be engaged when some of the examples highlight the clinical consequences of mutations, relating them to structural consequences.
Alternate splicing, post-translational changes, primary, secondary, tertiary, and quaternary protein structure, topology, domains, and chaperones are explained, followed by a survey of functional and structural categories of proteins, each with examples. The title, Genomics and Proteomics, may be somewhat of a misnomer, because only the first few of 55 pages deal with genomics, and the chapter gets to proteomics in the strict sense only at the end. The ribosome is a ribozyme.” Chapter 2 strongly emphasizes protein three-dimensional structure. “Cells take ribosomes very seriously.” (Did you know that the 15,000 ribosomes in each Escherichia coli cell constitute 25% of its mass?) About the crystal structure of the ribosome: “The results came as a shock. Online Resource Centre The Online Resource Centre to accompany Introduction to Protein Science features: For students.Answers to end-of-chapter exercises, and hints to end-of-chapter problems, so students can check their understanding.Rotating structures from the book to help students visualize proteins in 3D.Web-based problems for students to complete online. Active learning is encouraged by the provision of frequent exercises and problems, with further 'weblems' - web-based problems - on the Online Resource Centre. The practical applications of our knowledge to diverse fields such as biotechnology and medicine are emphasized throughout, to help students appreciate the relevance of the subject to the real world. Introduction to Protein Science, 3rd edition provides a rich and broad introduction to this fascinating field by covering not only the structure and function of proteins, but also the methods and experimental techniques used to study them. Indeed, by studying amino acid sequences and protein structures it is even possible to unravel some of the mysteries of evolution itself. In fact, the more they are studied, the more proteins continue to reveal new and exciting functions.
Over the last century, the centrality of proteins to life on earth has become increasingly clear - from forming enzymes acting as catalysts for specific reactions, to crucial molecules such as antibodies in the immune system, and as signalling molecules between cells.
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